- Details
-
Also available in:
- Parent Category: Knowledge Base
- Hits: 115
In the 1970s, scientists discovered the first incretin hormone, GIP (Glucose-Dependent Insulinotropic Polypeptide), and later identified the second incretin hormone: Glucagon-Like Peptide-1 (GLP-1). GLP-1 is secreted by intestinal L cells in the distal small intestine and proximal colon, encoded by the proglucagon gene, and is a polypeptide consisting of 30 amino acids[1-3].
- Details
-
Also available in:
- Parent Category: Knowledge Base
- Hits: 886
The development of society is closely linked to the labor force. Workers contribute their wisdom, skills, and sweat, creating numerous advancements in science, technology, and cultural arts. With the progress and changes in technology and culture, people's lifestyles are gradually evolving. Due to the rapid development of society, modern individuals are inclined towards highly defined and efficient ways of living. However, this shift has led to a sudden increase in the prevalence of mental illnesses due to the neglect of the spiritual world.
- Details
-
Also available in:
- Parent Category: Knowledge Base
- Hits: 897
Aflatoxins are a group of compounds characterized by a basic structure containing a dihydrofuran ring and coumarin (oxygenated naphthalene ketone). Their presence poses a serious threat to food safety, with risks to human health that cannot be ignored. Therefore, the detection of aflatoxins is crucial in the food safety production process.
- Details
-
Also available in:
- Parent Category: Knowledge Base
- Hits: 944
Directed immobilization technology is a method that utilizes specific techniques and materials to immobilize target molecules or substances at predetermined locations or on designated carriers. This technique finds wide-ranging applications in various fields including biomedicine, materials science, and environmental monitoring. In research experiments across these domains, directed immobilization technology effectively enhances detection efficiency while reducing workload and research costs. As an efficient research strategy, it is widely adopted and extensively researched across scientific disciplines.
- Details
-
Also available in:
- Parent Category: Knowledge Base
- Hits: 1034
Targeted Protein Degradation (TPD) technology has rapidly evolved over the past two decades as a method to disrupt protein function. The aim of this technology is to selectively degrade specific proteins, thereby modulating cellular processes and signaling pathways.
- Details
-
Also available in:
- Parent Category: Knowledge Base
- Hits: 886
Nanobodies are regarded as promising strategies and tools in both targeted detection and clinical treatment fields. However, research on targeted detection and clinical treatment of Helicobacter pylori (HP) primarily focuses on peptides, single-chain antibodies (scFv), yolk antibodies, and monoclonal antibodies. Despite their high affinity, good stability, low immunogenicity, small molecular size, and ease of modification, there have been no significant reports on the development of effective nanobody drugs for targeting Helicobacter pylori.
- Details
-
Also available in:
- Parent Category: Knowledge Base
- Hits: 780
Recently, Johnson & Johnson (JNJ) announced that its developed bispecific antibody, Rybrevant (amivantamab), has received full approval from the U.S. FDA for its use in combination with chemotherapy (carboplatin and pemetrexed) for the first-line treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) patients.
- Details
-
Also available in:
- Parent Category: Knowledge Base
- Hits: 738
Winter is the peak season for acute cardiovascular and cerebrovascular events. Cold weather can lead to elevated blood pressure and cerebral vasospasm, increasing the likelihood of cerebrovascular disease. Myocardial infarction and sudden cardiac death are also associated with cold temperatures. Studies have shown that for every 1°C decrease in temperature, the incidence of heart disease increases by approximately 2%. Traditional treatment strategies typically involve methods such as reducing fat, improving metabolism, dilating blood vessels, or clearing vascular blockages. However, these strategies still have many limitations.