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GZMK(Granzyme K, 颗粒酶K)是一种丝氨酸蛋白酶,属于Granzyme家族。它是细胞毒性淋巴细胞的主要效应分子之一,参与诱导靶细胞凋亡的过程。它通过水解特定肽键来发挥其酶活性,这些肽键通常位于靶细胞内的蛋白质上。通过切割这些蛋白质,GZMK可以触发细胞凋亡程序,导致靶细胞死亡。这使得GZMK在免疫系统清除被感染的细胞或癌细胞等过程中起着重要作用[1]。
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