- Details
- Parent Category: 知识文库
- Hits: 1197
GZMK(Granzyme K, 颗粒酶K)是一种丝氨酸蛋白酶，属于Granzyme家族。它是细胞毒性淋巴细胞的主要效应分子之一，参与诱导靶细胞凋亡的过程。它通过水解特定肽键来发挥其酶活性，这些肽键通常位于靶细胞内的蛋白质上。通过切割这些蛋白质，GZMK可以触发细胞凋亡程序，导致靶细胞死亡。这使得GZMK在免疫系统清除被感染的细胞或癌细胞等过程中起着重要作用[1]。
NBLST
Nanobody-Powered Canine Cancer Immunotherapy Ushers in a New Era for Companion Animal Health
With the groundbreaking progress of immune checkpoint inhibitors (ICIs) in human cancer therapy, the demand for similar treatments in companion animals, such as dogs, is increasingly growing....
September 19, 2025
Targeting HSV gB Protein Nanobody Breakthrough Reconfirms Solution to Herpesvirus Treatment Challenges
Herpes Simplex Virus (HSV) is primarily categorized into HSV-1 and HSV-2. The former often causes oral herpes, while the latter is a major cause of genital herpes. Both viruses can disseminate to...
September 12, 2025
Targeting mGlu to Ameliorate Behavioral Deficits Associated with NMDA Receptor Hypofunction
The lack of effective treatments for brain disorders related to NMDA receptor hypofunction, such as schizophrenia and GRIN1-related disorders, has long been a major challenge in the medical field....
September 05, 2025